Impaired neurotransmitter amine metabolism in arginase deficiency.
نویسندگان
چکیده
منابع مشابه
Mechanisms of Biogenic Amine Neurotransmitter Transporters
The biogenic amine transporters, as described in Chapters 1, 3, and 5 of this book, terminate the action of released biogenic amine neurotransmitters. These transporters utilize norepinephrine (NE), dopamine (DA), and serotonin (5-HT), and are referred to as NET, DAT, and SERT, respectively. Interruption of their function by agents such as antidepressants and stimulants causes profound changes ...
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The mitochondrial arginase type II (Arg-II) has been shown to interact with ribosomal protein S6 kinase 1 (S6K1) and mitochondrial p66Shc and to promote cell senescence, apoptosis and inflammation under pathological conditions. However, the impact of Arg-II on organismal lifespan is not known. In this study, we demonstrate a significant lifespan extension in mice with Arg-II gene deficiency (Ar...
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Deficiency of liver arginase (AI) causes hyperargininemia (OMIM 207800), a disorder characterized by progressive mental impairment, growth retardation, and spasticity and punctuated by sometimes fatal episodes of hyperammonemia. We constructed a knockout mouse strain carrying a nonfunctional AI gene by homologous recombination. Arginase AI knockout mice completely lacked liver arginase (AI) act...
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Arginase deficiency is caused by deficiency of arginase 1 (ARG1), a urea cycle enzyme that converts arginine to ornithine. Clinical features of arginase deficiency include elevated plasma arginine levels, spastic diplegia, intellectual disability, seizures and growth deficiency. Unlike other urea cycle disorders, recurrent hyperammonemia is typically less severe in this disorder. Normalization ...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1985
ISSN: 0022-3050
DOI: 10.1136/jnnp.48.11.1188-a